1. Basic Information

  • Chemical Name: Baicalin (also known as Baicalein-7-O-β-D-glucuronide).
  • CAS Number: 21967-41-9 (reference standard).
  • Molecular Formula: C₂₁H₁₈O₁₁
  • Molecular Weight: 446.36
  • Source: Extracted from the dried roots of Scutellaria baicalensis (Lamiaceae family).

2. Physicochemical Properties

  • Appearance: Pale yellow to brownish-yellow crystalline powder at room temperature; bitter taste.
    • Color Reactions:
      • Turns green upon reaction with ferric chloride (FeCl₃);
      • Forms orange precipitate with lead acetate.
  • Solubility:
    • Sparingly soluble in methanol, ethanol, and acetone;
    • Slightly soluble in chloroform and nitrobenzene;
    • Practically insoluble in water;
    • Soluble in hot acetic acid.
  • Stability:
    • Store in a cool, dry place, protected from light and strong oxidizers.

3. Pharmacological Actions

  • Anti-inflammatory & Anti-allergic:
    • Inhibits histamine release from mast cells and reduces capillary permeability, alleviating asthma and skin allergic reactions.
  • Antimicrobial & Antiviral:
    • Suppresses pathogens like Shigella dysenteriae, Staphylococcus, and influenza virus; clinically used for trachoma treatment.
  • Hepatoprotective & Choleretic:
    • Reduces hepatocyte damage, promotes bile secretion, and improves liver function.
  • Antioxidant & Anticancer:
    • Scavenges free radicals, induces tumor cell apoptosis, and inhibits proliferation of S180 and Hep-A-22 cancer cells.
  • Additional Effects:
    • Hypotensive, sedative, diuretic, and regulates lipid metabolism.

4. Product Specifications & Applications

  • Specifications:
    • Purity: ≥85% (HPLC-determined), customizable to 80%-99%.
    • Packaging: 25 kg cardboard drums or small aluminum foil bags.
  • Applications:
    • Pharmaceuticals: Raw material for drug formulations.
    • Cosmetics: Natural antioxidant and skin-brightening agent.
    • Food/Dye: Natural pigment and health supplement additive.

5. Production & Suppliers

  • Primary Manufacturer:
    • Qinghai Xidu Pharmaceutical Co., Ltd.
  • Pricing: Available upon request (varies by purity and specifications).